Developmental 2023 Timeseries smRNA analysis
Developmental 2023 Timeseries smRNA analysis
Pico Methyl-Seq library prep checks
Pico Methy-Seq Library Prep checks for E5 samples
Pico Methyl-Seq library prep
Pico Methy-Seq Library Prep for E5 samples
PCR adapter clean-up e5 samples
PCR adapter clean-up w/ e5 deep dive DNA samples
October 2024 Goals
October 2024 goals and daily notebook entries.
October 2024 Goals
October 2024 goals and daily notebook entries.
MiniPrep Plus DNA/RNA extractions
Extractions for e5 time series
Qubit e5 samples
Qubit w/ e5 timeseries DNA samples
Nanodrop e5 samples
Nanodropping e5 deep dive DNA samples and WGBS libraries
September 2024 Goals
September 2024 goals and daily notebook entries.
Metabolomic extraction
e5 test samples for metabolomics
Pico Methyl-Seq library prep
Pico Methy-Seq Library Prep test for E5 samples
e5 closest
e5 deep dive - extending genes to identify 3’ UTRs
e5 closest
e5 deep dive - looking at closest genes to ncRNAs
MiniPrep Plus DNA/RNA extractions
Extractions for e5 time series
MiniPrep Plus DNA/RNA extractions
Extractions for e5 time series
August 2024 Goals
August 2024 goals and daily notebook entries.
July 2024 Goals
July 2024 goals and daily notebook entries.
E5 Deepdive Mirna Targetprediction
Options for 3’ UTR prediction
Pico Methyl-Seq library prep
Pico Methy-Seq Library Prep test for E5 samples
Pico Methyl-Seq library prep
Pico Methy-Seq Library Prep test for E5 samples
miRNA library prep
miRNA library prep for Mcap developmental time series Hawaii 2023
miRNA library prep
miRNA library prep for Mcap developmental time series Hawaii 2023
miRNA library prep
miRNA library prep for Mcap developmental time series Hawaii 2023
June 2024 Goals
June 2024 goals and daily notebook entries.
RiboFree library prep
RiboFree library prep test for Mcap developmental time series Hawaii 2023
RiboFree library prep
RiboFree library prep test for Mcap developmental time series Hawaii 2023
ITS2 sequencing plates
ITS2 samples + plate maps for sequencing
ITS2 clean-up
This post details information on ITS2 clean-up for the my ambient Mcap developmental timeseries samples from 2023 and for the POC spawning experimental samples from 2023. Mcap 2023 github repo is here and POC github is here. See Ariana’s post about the ITS2 protocol for this project.
ITS2
ITS2 for Mcap developmental timeseries Hawaii 2023 and POC spawning 2023 sample
ITS2
ITS2 for Mcap developmental timeseries Hawaii 2023 and POC spawning 2023 sample
ITS2
ITS2 for Mcap developmental timeseries Hawaii 2023 and POC spawning 2023 sample
RNA Qubit tests
Concentrations for ITS2
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap developmental time series Hawaii 2023
Pacuta SRA uploads to NCBI
Genome submission to NCBI
Pacuta SRA uploads to NCBI
SRA uploads to NCBI
May 2024 Goals
May 2024 goals and daily notebook entries.
ITS2 clean-up for Mcap C/D
ITS2 for Mcap larvae C/D Hawaii 2023 experiment
ITS2 clean-up test for Mcap C/D
ITS2 for Mcap larvae C/D Hawaii 2023 experiment
e5 deep dive ncRNA protein machinery
e5 deep dive - investigating ncRNA protein machinery in 3 species of corals
SwitchFree library prep
SwitchFree library prep test
MiniPrep Plus DNA/RNA extractions
Extractions for Moorea Pocillopora spawning 2023
April 2024 Goals
April 2024 goals and daily notebook entries.
SwitchFree library prep
SwitchFree library prep test
Developmental 2023 Timeseries mRNA analysis (initial)
Developmental 2023 Timeseries mRNA analysis (initial)
MiniPrep Plus DNA/RNA extractions
Extractions for Moorea Pocillopora spawning 2023
Pacuta HI 2022
Pacuta 2022 BLAST
miRNA library prep
miRNA library prep for Mcap developmental time series Hawaii 2023
miRNA library prep
miRNA library prep for Mcap developmental time series Hawaii 2023
miRNA library prep
miRNA library prep for Mcap developmental time series Hawaii 2023
March 2024 Goals
March 2024 goals and daily notebook entries.
miRNA library prep
miRNA library prep for Mcap developmental time series Hawaii 2023
RiboFree library prep
RiboFree library prep test for Mcap developmental time series Hawaii 2023
RiboFree library prep
RiboFree library prep test for Mcap developmental time series Hawaii 2023
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap developmental time series Hawaii 2023
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap developmental time series Hawaii 2023
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap developmental time series Hawaii 2023
Apulchra genome assembly
Apulchra genome assembly
February 2024 Goals
February 2024 goals and daily notebook entries.
Mcap Ribofree expression test
I am deciding what kind of depth/coverage I will need for sequencing if I proceed with the Zymo Ribofree library prep kit. I am using the gene count matrices generated through the Express Compare project. In this post, I looked at all of the Mcap Ribofree gene count matrices that I could find to assess how many genes were retained before and after filtering. I did a two-step filtering process - first, I removed all rows whose sum was zero (ie those genes were not expressed at all). Then I applied the pOverA(0.75,5).
Pacuta HI 2022
Pacuta 2022 mRNA analysis
Astrangia 2021 lncRNA analysis
Astrangia 2021 lncRNA analysis
RiboFree library prep
RiboFree library prep test for Mcap developmental time series Hawaii 2023
January 2024 Goals
January 2024 goals and daily notebook entries.
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
December 2023 Goals
December 2023 goals and daily notebook entries.
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
November 2023 Goals
November 2023 goals and daily notebook entries.
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
MiniPrep Plus DNA/RNA extractions
Extractions for A. pulchra IGA and CGA Moorea 2022
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap developmental time series Hawaii 2023
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap developmental time series Hawaii 2023
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
RNA Qubit tests
Qubit RNA tests
RNA QC
I have been having some discrepancies in my RNA QC data for AH’s sample. I have been getting “Sample too low” for a lot of samples on the Qubit, but when I run the same samples on the Tapestation, I get pretty solid concentrations. I wanted to compare data from past extractions that have done both Qubit and Tapestation. Erin Chille did RNA extractions for an Mcap 2018 larval experiment and a Ahya 2018 gamete experiment where she did Qubit and Tapestation QC on the samples. I compared those results in the figures and tables below.
Tapestation for Mcap larvae C/D
I ran the Tapestation today based on Maggie’s tapestation protocol. I ran 5 samples from AH’s experiment that failed the Qubit. The samples that I ran were R43, R54, R59, R88, and R94. R43 was extracted on 10/5/23, R59 & R94 were extracted on 9/11/23, and R54 & R88 were extracted on 9/16/23
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
October 2023 Goals
October 2023 goals and daily notebook entries.
Lipid assay
20230915 Lipid assay test
Tapestation for Mcap larvae C/D
I ran the Tapestation today based on Maggie’s tapestation protocol. I ran 4 samples from AH’s experiment that failed the Qubit. The samples that I ran were R17, R48, R98, and R107. R17 and R107 was extracted on 9/11/23 and R48 and R98 was extracted on 9/16/23.
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
September 2023 Goals
September 2023 goals and daily notebook entries.
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
Lipid assay
20230915 Lipid assay test
Lipid assay
Test of lipid assay protocol
Bermuda 2023 daily notebook posts
This post includes the full notebook for the July-August 2023 Diploria labyrinthiformis coral spawning and field expedition in Bermuda at the Bermuda Institute of Ocean Sciences. My project will focus on development of D. labyrinthiformis larvae through their use of energetic stores and expression of coding and non-coding transcripts. The ENCORE team (Dr. Hollie Putnam (URI), Dr. Gretchen Goodbody-Gringley (CCMI), Dr. Sam de Putron (BIOS), Dr. Yvonne Sawall (BIOS), Dr. Brett Jameson (BIOS), Dr. Chloe Carbonne (BIOS, Flo Fields (URI), and Hailey Davis (CCMI)) are also here doing a variety of experiments with D. labyrinthiformis and Porites astreoides. Githubs for the ENCORE projects are here. Github for the developmental timeseries is here.
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
MiniPrep Plus DNA/RNA extractions
Extractions for Mcap larvae C/D Hawaii 2023 experiment
MiniPrep Plus DNA/RNA extractions - test
Extractions for Mcap larvae C/D Hawaii 2023 experiment
Hawaii 2023 daily notebook posts
This post includes the full notebook for the June-July 2023 Montipora capitata coral spawning and field expedition in Hawaii at the Hawaii Institute of Marine Biology. My project will focus on development of M capitata larvae through their use of energetic stores and expression of coding and non-coding transcripts. Dr. Ariana Huffmyer is also conducting experiments on M. capitata larvae; her experiments are detailed in her Github notebook here. Github for the developmental timeseries is here.
Astrangia 2021 small RNA analysis
Astrangia 2021 small RNA analysis
Astrangia2021 Sequencing Information
Sample information from Astrangia 2021 project
MiniPrep Plus DNA/RNA extractions
Extractions for Astrangia 2021 experiment
E5 deep-dive into long non-coding RNAs
This post details analysis and bioinformatic steps to generate a long non-coding RNA count matrix from RNAseq data for the E5 Deep Dive Project. More information on this project can be found here.
Power analysis for RNAseq
Conducting a power analysis for RNASeq data
Astrangia 2021 mRNA analysis
Astrangia 2021 mRNA analysis
Point Judith Oyster Nutrient DNA methylation
Point Judith oyster DNA methylation
RNA clean and concentrate protocol
This protocol describes how to clean/concentrate RNA with the Zymo RNA Clean & Concentrator-5 kit.
Obsidian installation and use
Using Obsidian and Paperpile to take notes
Ash free dry weight protocol
Goal: Determine ash-free dry weight in Astrangia samples from 2021 experiment
Symbiont cell density protocol
Goal: Determine symbiont cell densities in Astrangia samples from 2021 experiment
Chlorophyll-a protocol
Goal: Determine chlorophyll-a in Astrangia samples from 2021 experiment
Autoclave Use
The first floor autoclave in CBLS is in room 178. It is usually unlocked, but may require swipe access.